U.S. Route 67 is a major north–south United States highway that stretches over 1,560 miles from the U.S.-Mexico border in Presidio, Texas, to Sabula, Iowa, where it intersects U.S. Route 52. This route serves as a vital corridor connecting the arid Southwest with the Midwest, cutting across diverse terrains, from desert landscapes to rolling farmland and busy metropolitan areas.

In Texas, US 67 begins at the international bridge in Presidio and travels northeast through West Texas cities like Alpine, San Angelo, and Dallas. It shares alignments with major highways like I-10 and I-35 at various points. As it moves into Arkansas, US 67 becomes a key expressway corridor paralleling Interstate 30 and serving as a major route between Texarkana and Little Rock. Notably, parts of this highway in Arkansas are being upgraded to interstate standards and have become part of the Interstate 57 extension.

Continuing northward, US 67 crosses the Mississippi River into Missouri via the Bill Emerson Memorial Bridge and traverses southeast Missouri, intersecting with major routes such as US 60 and US 61. In Illinois and Iowa, the route winds through scenic river towns and agricultural communities before reaching its terminus in Sabula. Along its journey, US 67 supports both regional commerce and tourism, offering travelers access to historic sites, natural landmarks, and urban centers.