U.S. Route 60 (US 60) is a major east–west United States highway that stretches over 2,600 miles from the deserts of Arizona to the Atlantic coast of Virginia. Originally part of the U.S. Highway System established in 1926, it serves as a vital corridor across the southern Midwest and Appalachia. Though it was once proposed to extend to Los Angeles, today the highway begins in western Arizona at an interchange with Interstate 10 near Brenda and ends in Virginia Beach, Virginia.

Traveling through a diverse cross-section of the country, US 60 passes through several major cities and regions, including Amarillo, Texas; Oklahoma City, Oklahoma; Springfield, Missouri; Lexington, Kentucky; and Charleston, West Virginia. In some areas, it parallels or overlaps with other major highways such as US 62, US 66 (in its historic alignments), and parts of Interstate 64. Along the way, US 60 transitions from desert landscapes to rolling plains, forested hills, and Appalachian mountain terrain, making it a route rich in scenic variety.

Historically, US Route 60 has played an essential role in facilitating regional commerce and cross-country travel. It remains heavily used in rural and urban areas alike. Numerous segments of US 60 have been upgraded to four-lane divided highways or freeways, particularly in Kentucky and West Virginia, where it serves as a key alternative to I-64. For road trip enthusiasts and transportation historians, US 60 offers a glimpse into both the historical development of America’s roadways and the continuing evolution of modern highway infrastructure.