Explore Interstate 64, a vital east–west highway stretching from Missouri to Virginia. Learn about its major cities, scenic sections, and regional importance across the Midwest and Appalachia.
Interstate 64 is a major east–west corridor that stretches from the Midwestern heartland to the Atlantic coast. The route begins in Wentzville, Missouri, a western suburb of St. Louis, where it connects with I-70. From there, it travels through southern Illinois, Indiana, and Kentucky before entering the Appalachian region. In West Virginia and Virginia, the highway winds through mountainous terrain and historically significant cities, ultimately terminating in Chesapeake, Virginia, near the Atlantic Ocean.
Notably, I-64 links several major urban centers including St. Louis, Louisville, Lexington, Charleston, and Richmond. Its path offers a blend of metropolitan travel and scenic drives—especially in Kentucky’s Bluegrass region and the rugged sections of the Appalachian Mountains. This makes it an important route not just for commerce and commuting, but also for tourism and long-distance travel.
Throughout its length, I-64 overlaps with other major routes, including concurrencies with I-55 and I-57 in Illinois, I-75 in Kentucky, and I-77 in West Virginia. Its role in connecting the Midwest to the Atlantic coast makes it a vital transportation artery in the eastern United States.
Take a scenic 95-mile journey along Interstate 64 from Louisville to Interstate 69 in Indiana, passing through New Albany, Corydon, and the forests of southern Indiana. This drive offers wooded landscapes, historic towns, and peaceful rural stretches perfect for a relax…
Cruise 57 miles west on Interstate 64 from Frankfort to Louisville, Kentucky. This route blends pastoral Bluegrass scenery with urban infrastructure, passing through Shelbyville, the I-265 beltway, downtown Louisville, and across the Ohio River into Indiana.
Cruise Interstate 64 west from Lexington to Frankfort, Kentucky, and discover scenic horse farms, the charming town of Midway, and sweeping views of the Kentucky River before arriving at the state capital. Perfect for road trippers, commuters, and anyone exploring Kentu…
Take a 5-mile drive westbound on Interstate 64 through St. Louis, Missouri — from downtown’s trench highway to the cultural corridor of Forest Park and out to Brentwood Boulevard. Explore this vital urban stretch packed with landmarks, history, and commuter routes.
Travel Interstate 64 eastbound through St. Louis, Missouri on a 6-mile drive from Brentwood Blvd to 14th Street, passing Forest Park, the Science Center, and entering downtown via double-deck freeway segments.
Drive 77 miles east along Interstate 64 from I-69 near Evansville to Corydon, Indiana. This peaceful route travels through farmland, the Hoosier National Forest, and rolling hills of the Ohio River valley.
Follow Interstate 64 from the West Virginia state line to Lexington, Kentucky, on a scenic 110-mile drive through Appalachian hills, Daniel Boone National Forest, and Bluegrass country, connecting small towns and major highways.
Cruise along Interstate 64 from Charleston to Huntington, West Virginia, for 59 scenic miles through river valleys, historic towns, and vibrant Appalachian landscapes. Discover key interchanges, local history, and regional highlights in this detailed route guide.